Anti Estrogen Trilostane Vetoryl Bodybuilding

High Purity Bodybuilding Trilostane / Vetoryl CAS 13647-35-3  for Breast Cancer Treatment with manufacturer price

Trilostane 

Quick Detail: 

CAS No.:13647-35-3

Other Names:Trilostane

MF:C20H27NO3

Place of Origin:ShenZhen, China (Mainland)

Type:Trilostane

Grade Standard:Medicine Grade

Brand Name:SENDI

Model Number:API

Purity:99.9%min

CAS:13647-35-3

Shelf life:2 Years

Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg195 in 3∫-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 3β-HSD, but not 3β-HSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular production of ,  and dihydro  in LNCaP-FGC prostate cancer cells and inhibiting cortisol biosynthesis in the human adrenal gland. This product serves as a useful tool in steroid biosynthesis research.

Function

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6)Headquartered in Shanghai, Shanghai is one of the world's largest port, convenient for the customes provide logistics services.
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 Application

 Trilostane can suppress cortical hormone synthesis process of 3 beta dehydrogenase, make cortisol, aldosterone synthesis reduce, clinical used in the treatment of Cushing syndrome(cortisol increase disease) and primary aldosteronism,the effect is not good than metyrapone. This product has significantly reduced blood level role, may relevant to its inhibit synthetic.

Specification

What is Trilostane?
Trilostane (4α, 5α-epoxy-17β-hydroxy-3-oxoandrostane-2α-carbonitrile) is an orally active synthetic steroid analogue that selectively inhibits 3 β-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone. This inhibition blocks production of glucocorticoids and to a lesser extent, mineralocorticoids and sex hormones while steroid precursor levels increase.

Usages and Functions:

Usage : Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.

Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible. Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.

Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.

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