High Purity Bodybuilding Trilostane / Vetoryl CAS 13647-35-3 for Breast Cancer Treatment with manufacturer price
Trilostane
Quick Detail:
CAS No.:13647-35-3
Other Names:Trilostane
MF:C20H27NO3
Place of Origin:ShenZhen, China (Mainland)
Type:Trilostane
Grade Standard:Medicine Grade
Brand Name:SENDI
Model Number:API
Purity:99.9%min
CAS:13647-35-3
Shelf life:2 Years
Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg195 in 3∫-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 3β-HSD, but not 3β-HSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular production of , and dihydro in LNCaP-FGC prostate cancer cells and inhibiting cortisol biosynthesis in the human adrenal gland. This product serves as a useful tool in steroid biosynthesis research.
Function
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Application
Trilostane can suppress cortical hormone synthesis process of 3 beta dehydrogenase, make cortisol, aldosterone synthesis reduce, clinical used in the treatment of Cushing syndrome(cortisol increase disease) and primary aldosteronism,the effect is not good than metyrapone. This product has significantly reduced blood level role, may relevant to its inhibit synthetic.
Specification
Test Item | Analysis Specification | Result |
Description | White to off-white power | Conforms |
Purity | 99%min | 99.9% |
Water(K.F) | ≤0.5% | 0.20% |
Loss on drying | ≤0.5% | 0.26% |
Residue on ignition | ≤0.1% | 0.04% |
Heavy metals | ≤20ppm | <20ppm |
Specific optional rotation | +137°~ +139° | +138.8° |
Conclusion | Conform to Company Standard. |
What is Trilostane?
Trilostane (4α, 5α-epoxy-17β-hydroxy-3-oxoandrostane-2α-carbonitrile) is an orally active synthetic steroid analogue that selectively inhibits 3 β-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone. This inhibition blocks production of glucocorticoids and to a lesser extent, mineralocorticoids and sex hormones while steroid precursor levels increase.
Usages and Functions:
Usage : Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.
Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible. Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.
Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
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