Letrozole / Femara CAS 112809-51-5 Anti Estrogen Steroids For Anti Cancer
Product Name: Letrozole / Femara:
Synonyms: 4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE;FEMARA;CGS-20267;LETROZOL;LETROZOLE;LetrozoleUsp28;Letrozole99%;CGS-20267, Femara
Letrozole Chemical Properties:
Chemical Properties Melting point is 181～183 oC.
Usage Pyrrole type aromatization enzyme inhibitors. Used in the treatment of breast cancer.
This information is edited by ChemicalBook Xiao Nan.
Production Method 4-bromine methyl phenyl nitrile (I) and triazole react in chloroform, products (Ⅱ) and 4-fluorine benzene nitriles react in dimethyl formamide, generate to letrozole in the presence of potassium tert-butyl alcohol.
Chemical Properties white to light yellow crystal
Usage A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic
Letrozole is a potent aromatase inhibitor for breast cancer. For athletes and bodybuilders, it is a medicament for estrogen side effects against synthetic metabolic steroids, acne and celiac disease. Due to decreased estrogen in the body, can also cause elevated testosterone levels. Side effects of letrozole include reduced sexual behavior, continuous use can lead to decreased lipid function and immune system damage.
Letrozole Mechanism of action:
Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Estrogens then bind to an estrogen receptor, which causes cells to divide. Letrozole is an aromatase inhibitor.
Letrozole prevents the aromatase from producing estrogens by competitive, reversible binding to the heme of its cytochrome P450 unit. The action is specific, and letrozole does not reduce production of mineralo- or corticosteroids.
Femara is a powerful Aromatase Inhibitor that was developed to fight breast cancer. For athletes and bodybuilders, it is a drug used to combat the estrogenic side effects of anabolic steroids water-retention, acne and gynocomastia. It will also raise testosterone levels because of the lowered estrogen in the body. Side effects from include a lowered sex drive and continuous use can lead to lowered lipid function and an impaired immune system.
Letrozole is an aromatase inhibitor. It works by reducing the total amount of estrogen produced primarily in the body. This helps to starve cancer cells by depriving them of estrogen.
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