1, Fulvestrant/ Faslodex Profile:
Product Name: Fulvestrant
Alias: Faslodex
Chemical Name: (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol
CAS#: 129453-61-8
MF: C32H47F5O3S
MW: 606.77
Chemical structure:
Appearance: White to off-white powder
Assay (on anhydrous basis) : 98.9%
Standard: Enterprise standard (we also make USP standard Fulvestrant powder which is a little more expensive)
Method: By HPLC & IR
Melting point: 104-106°C
Storage temp.: 2-8°C
Solubility DMSO: >5 mg/ml
Routes of administration: Intramuscular injection
Half life: 40 days
Usage: Antiestrogen; A novel steroidal estrogen antagonist reported to lack any partial agonist activity. Antineoplastic (hormonal).
2, Applications of Fulvestrant/ Faslodex:
Fulvestrant (trade name Faslodex) is a medication used to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women with disease progression as well as HR-positive, HER2-negative advanced breast cancer in combination with palbociclib in women with disease progression after endocrine therapy. It is given by injection into a muscle.
Fulvestrant is a selective estrogen receptor degrader (SERD) and was first-in-class to be approved. It works by binding to the estrogen receptor and destabilizing it, causing the cell's normal protein degradation processes to destroy it.
Fulvestrant was approved for medical use in the United States in 2002.
Faslodex is liquid that is given once a month as an injection into a muscle, usually at your doctor's office. Women usually get Faslodex as long as it is effectively treating the cancer.
Benefits of Faslodex
Research has shown that Faslodex works as well as or better than Arimidex (chemical name: anastrozole), an aromatase inhibitor, in slowing or stopping the growth of metastatic (breast cancer that has spread to other parts of the body), hormone-receptor-positive breast cancer in postmenopausal women after tamoxifen has stopped working.
3, COA of Fulvestrant/ Faslodex Powder:
4, Fulvestrant/ Faslodex Powder Picture:
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