Hormonal Steroids Letrozole / Femara CAS 112809-51-5 for Anticancer
Product Name: Letrozole
Synonyms: 4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE;FEMARA;CGS-20267;LETROZOL;LETROZOLE;LetrozoleUsp28;Letrozole99%;CGS-20267, Femara
CAS: 112809-51-5
MF: C17H11N5
MW: 285.3
Letrozole Chemical Properties
Chemical Properties Melting point is 181～183 oC.
Usage Pyrrole type aromatization enzyme inhibitors. Used in the treatment of breast cancer.
This information is edited by ChemicalBook Xiao Nan.
Production Method 4-bromine methyl phenyl nitrile and triazole react in chloroform, products and 4-fluorine benzene nitriles react in dimethyl formamide, generate to letrozole in the presence of potassium tert-butyl alcohol.
Chemical Properties white to light yellow crystal
Usage A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic
Tests | Specifications | Results |
Appearance | White or off-white crystaline powder | White |
Solubility | Soluble in ethanol when heated | Conform |
ldentification | (1)Maximum absorption in wavelength of 240 nm | Conform |
(2)Infrared spectrum should be in accordance the dominant peak of contrast | In accordance with the dominant peak of contrast | |
Melting points | 182ºC-184ºC | 182ºC |
Related substances | ≤0.5% | 0.3% |
Single impurity | ≤0.3% | 0.2% |
Loss on drying | ≤1.0% | 0.8% |
Conclusion | Conforms Specifications of Enterprise Standard. | |
Letrozole use
This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Letrozole is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Letrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.
Letrozole doasge
Take letrozole on a regular schedule to get the most benefit from it.
If you miss a dose of letrozole, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use letrozole.
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