Dantrolene Sodium Muscle Relaxant Drug

Dantrolene Sodium CAS 24868-20-0 Muscle relaxant drug Product Name: Dantrolene Sodium CAS NO: 24868-20-0 Apperance: Yellowish-orange to orange crystalline powder Specification: Heavy metals: Not more than 20ppm Water:...
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Product Details

Dantrolene Sodium CAS 24868-20-0 Muscle relaxant drug 


Product Name: Dantrolene Sodium

CAS NO: 24868-20-0

Apperance: Yellowish-orange to orange crystalline powder

Specification:

Heavy metals: Not more than 20ppm

Water: 14.5~17.0%

Impurity A: ≤ 0.15%

Impurity B: ≤ 0.40%

Impurity C: ≤ 0.15%

Single biggest unknown impurities: ≤0.10%

Total impurities: ≤0.60%

Chloride: Not more than 0.02%

Sodium:5.5~6.0%

Assay: 98.0%~102.0% of C14H9N4NaO5 on the dried basis


Uses

This medication is used to treat muscle tightness and cramping (spasms) caused by certain nerve disorders such as spinal cord injury, stroke, cerebral palsy, and multiple sclerosis. It works by relaxing the muscles. Dantrolene helps reduce muscle pain and stiffness, improves your ability to move around, and lets you do more of your daily activities.

Dantrolene is also used with other treatments to prevent or treat special cases of high fever (malignant hyperthermia) related to anesthesia and surgery.


How to use Dantrolene SODIUM?

See also Warning section.

Take this medication by mouth as directed by your doctor. For the treatment of long-term muscle tightness/spasms, your doctor may slowly increase your dose to lower your chance of side effects until the right dose for you is determined. The manufacturer recommends that you do not take more than 400 milligrams per day.

Dosage is based on your medical condition, response to therapy, and in some cases weight. For the prevention and treatment of malignant hyperthermia, treatment lasts for several days.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.


Precautions

Before taking dantrolene, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems (such as hepatitis, cirrhosis), breathing problems (such as chronic obstructive pulmonary disease-COPD), heart problems.

This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Before having surgery, tell your doctors or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

COA:

ITEMS

      SPECIFICATIONS

    RESULTS

Characters

Yellow crystalline powder

Complies

Identification

a):TLC.

b):Sulphuric acid reaction a yellow colour develops

c):It gives reaction of chlorides

 

Complies

Assay

90%~100.0%(C22H24N2O8)

Based on anhydrous ethanol-free substance

99.9%

PH

2.0~3.0

2.4

Specific optical rotation

E (1%) is 300~335 at 349nm

325

Heavy Metals

≤50ppm

20ppm

Specific optical rotation

-1050~-1200

-1130

Light-absorbing impurities

At490nm≤0.07

0.02

Related substances

a) : β-epidoxycycline≤2.0%

b):metacycline≤2.0%

c):any other impurity≤0.5%

1.8%

0.3%

Not found

Ethanol

4.3~6.0%(m/m)

4.7%

Sulphated ash

≤0.4%

0.05%

Weter

1.4~2.8%

2.0%

Conclusion:

Conform to BP2005



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