Hormone Drugs Estriol For Treating Cervicitis

Hormone Drugs Estriol for Treating Cervicitis Product Name: Estriol Synonyms:...
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Hormone Drugs Estriol for Treating Cervicitis




Product Name: Estriol

Synonyms: TRIDESTRIN;(16-alpha,17-beta)-estra-1,3,5(10)-triene-3,16,17-triol;(16alpha,17beta)-Estra-1,3,5(10)-triene-3,16,17-triol;(16-alpha,17-beta)-oestra-1,3,5(10)-triene-3,16,17-triol;(16alpha,17beta)-Oestra-1,3,5(10)-triene-3,16,17-triol;1,3,5-estratriene-3-beta,16-alpha,17-beta-triol;1,3,5-Estratriene-3beta,16-alpha,17-beta-triol;1,3,5-oestratriene-3-beta,16-alpha,17-beta-triol

CAS: 50-27-1

MF: C18H24O3

MW: 288.38

EINECS: 200-022-2


Description

1. Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol.

2. Estriol may play a role in the development of breast cancer, but based on in vitro research, does appear to act as an antagonist to the G-protein coupled estrogen receptor. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada.Though initial research in the 1970s suggested it could be used therapeutically as an estrogen,subsequent research failed to confirm this hypothesis.In pregnant women with multiple sclerosis, estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.

3. Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol.

4. Estriol may play a role in the development of breast cancer, but based on in vitro research, does appear to act as an antagonist to the G-protein coupled estrogen receptor. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not

approved for use by the FDA or Health Canada.


COA

ITEMSPECIFICATIONRESULT
CharacterWhite or almost white crystalline powderWhite crystalline powder
Specific rotation+54°to +62°+59.9°
Completeness of solutionClear and free from undissolved solidConforms
Identification(1) complies by IR
(2) complies by UV
Conforms
Conforms
Residue on IgnitionNot more than 0.1%0.05%
Loss on dryingNot more than 0.50.1%
Chromatographic
purity
Total impurities not more than 2.0%<2.0%
AssayIt should contain 97.0% to 102.0% of C18H24O3 calculated on dried basis98.4%
Particle sizeIt should be 90% below 30μmConforms


Applications

Estriol's strength is actually found in its weakness. Tests show that while relieving the symptoms of perimenopause and menopause, estriol doesn't seem to increase the risk of breast cancer. This is because estriol binds to the estrogen receptors on the breast cells, but it has much weaker activity.

Therefore, it actually blocks the stronger estradiol from binding to those cells and subjecting them to the higher estrogenic activity which has been shown to be protective against breast cancer. And for women who have difficulty tolerating stronger estrogens for the treatment of hormonal imbalance due to aging, estriol is often the right choice.


Dosage

A chemical derivative of estradiol, ethinyl estradiol with maximum dosage 200 µg, is a major component of hormonal contraceptive devices. Combined forms of hormonal contraception contain ethinyl estradiol and a progestin, which both contribute to the inhibition of GnRH, LH, and FSH, which accounts for the ability of these birth control methods to prevent ovulation and thus prevent pregnancy. Other types of hormonal birth control contain only progestins and no ethinyl estradiol.

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