Powder Estrone Female Steroids Inhibitors

Powder Estrone Female Steroids Inhibitors Product Name: 1,3,5(10)-Estratrien-3-ol-17-one Synonyms:...
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Product Details

Powder Estrone Female Steroids Inhibitors




Product Name: 1,3,5(10)-Estratrien-3-ol-17-one

Synonyms: (8R,13S)-3-Hydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-cyclopenta[a]phenanthren-17-one;1,3,5(10)-Oestratrien-3-ol-17-one;1,3,5-Oestratrien-3-ol-17-one;3-Hydroxy-1,3,5-(10)-oestratrien-17-one;3-Hydroxy-1,3,5(10)-oestratrien-17-one;3-hydroxy-17-keto-estra-1,3,5-triene;3-Hydroxy-17-ketoestra-1,3,5-triene;3-hydroxy-17-keto-oestra-1,3,5-triene

CAS: 53-16-7

MF: C18H22O2

MW: 270.37

EINECS: 200-164-5


Description:

Estrone is one of the three naturally occurring estrogens, the others being estradiol and estriol.Estrone is synthesized from androstenedione by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver.Serum concentrations of estrone in premenopausal women fluctuate according to the menstral cycle and becomes the most predominant estrogen in postmenopausal women. The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol.


Estrogen is a steroid compounds have a wide range of biological activity, it is not only to promote and maintain the female reproductive organs and secondary sexual characteristics of the physiological role, and the endocrine system, the cardiovascular system, the body's metabolism, bone growth and

maturation, skin and other aspects have a significant impact.


Due to the secretion of estrogen, can nourish the skin, beautiful hair, and promote breast development

increased, reflecting the graceful curve of the body. So estrogen for women to maintain their youth and women second feature essential trace elements. In addition to the beauty estrogen plays an important role, and human health are closely linked.


Applications:

Estrone is known to be a carcinogen for human females as well as cause breast tenderness or pain, nausea, headache, hypertension, and leg cramps.In men, estrone has been known to cause anorexia, nausea, vomiting, and erectile disfunction. Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol. It is the predominant estrogen in postmenopausal women.


1. Supplement of estrogen. Commonly used in the treatment of female gonadal dysfunction, bilateral oophorectomy, atrophic vaginitis, genital dried menopause such as hot flashes, sweating and mental, neurological symptoms.

2. The use of estrogen therapy for metastatic breast cancer, 40% can be achieved remission.

3. For the treatment of advanced prostate cancer, symptoms improved, pain relief, after ORCHIECTOMY coupled with estrogen therapy.

4. To prevent osteoporosis, early menopause for the prevention of bone due to estrogen deficiency caused rapid loss.

5. Treatment of acne (acne), in men can be used for heavy cases, women can choose estrogen and progestogen combination preparation.

6. Leukopenia, used by cancer chemotherapy or radiotherapy-induced leukopenia, significantly elevated white blood cell effects.

7. Used as a morning-after pill.


Test ItemsSpecificationTest Results
DescriptionWhite or almost white crystalline powderWhite crystalline powder
Melting Point191.0~193.0ºC192ºC
Loss of drying≤1.0%0.5%
Heavy Metal≤20ppm15ppm
TLCOnly one spotOnly one spot
Assay≥99.5%99.91%

IMG_20160508_150339_副本

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