Steroid Hormone Powder Medroxyprogesterone Acetate

Steroid Hormone Powder Medroxyprogesterone Acetate Product Name: Medroxyprogesterone 17-acetate Synonyms:...
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Product Details

Steroid Hormone Powder Medroxyprogesterone Acetate

Product Name: Medroxyprogesterone 17-acetate

Synonyms: (6-alpha)-17-(acetyloxy)-6-methylpreg-4-ene-3,20-dione;17-(acetyloxy)-6-methyl-(6-alpha)-pregn-4-ene-20-dione;17-(acetyloxy)-6-methyl-20-dion(6alpha)-pregn-4-ene-;17-acetoxy-6-alpha-methylprogesterone;17-alpha-hydroxy-6-alpha-methylpregn-4-ene-3,20-dioneacetate;17-alpha-hydroxy-6-alpha-methyl-progesteronacetate;17-alpha-hydroxy-6-alpha-methylprogesteroneacetate;17-hydroxy-6-alpha-methylpregn-4-ene-3,20-dioneacetate

CAS: 71-58-9

MF: C24H34O4

MW: 386.52

EINECS: 200-757-9

What is Medroxyprogesterone Acetate

Medroxyprogesterone Acetate is a more potent derivative of its parent compound medroxyprogesterone (MP). Medroxyprogesterone is a synthetic variant of the steroid hormone progesterone(progestin). Progestins and estrogens are the two major classes of female hormones. While medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, what is almost always being referred to is MPA and not MP.

Chemical Properties

Melting point 206-207 °C(lit.)

alpha D +61° (in chloroform)

refractive index 48 ° (C=1, Dioxane)

storage temp. Refrigerator

Water Solubility <0.1 g/100 mL at 23 ºC

Merck 13,5817

Stability:Stable, but weakly air and light sensitive. Incompatible with strong oxidizing agents.


Highly effective at preventing pregnancy.

Injected every 12 weeks. The only continuing action is to book subsequent follow-up injections every twelve weeks, and to monitor side effects to ensure that they do not require medical attention.

No estrogen. No increased risk of deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, or myocardial infarction.

Minimal drug interactions (compared to other hormonal contraceptives).

Decreased risk of endometrial cancer. Depo-Provera reduces the risk of endometrial cancer by 80%.The reduced risk of endometrial cancer in Depo-Provera users is thought to be due to both the direct anti-proliferative effect of progestogen on the endometrium and the indirect reduction of estrogen levels by suppression of ovarian follicular development.

Decreased risk of iron deficiency anemia, pelvic inflammatory disease (PID), ectopic pregnancy, and uterine fibroids.

Decreased symptoms of endometriosis.

Decreased incidence of primary dysmenorrhea, ovulation pain, and functional ovarian cysts.

Decreased incidence of seizures in women with epilepsy. Additionally, unlike most other hormonal contraceptives, Depo-Provera's contraceptive effectiveness is not affected by enzyme-inducing antiepileptic drugs.

Decreased incidence and severity of sickle cell crises in women with sickle-cell disease.

Medical uses

1. Birth control

Estimates of first-year failure rates are about 0.3%.

2. Perfect use

Trussell's estimated perfect use first-year failure rate for medroxyprogesterone acetate by injection as the average of failure rates in seven clinical trials at 0.3%. It was considered perfect use because the clinical trials measured efficacy during actual use of medroxyprogesterone acetate defined as being no longer than 14 or 15 weeks after an injection (i.e., no more than 1 or 2 weeks late for a next injection).






: White Crystalline Powder

White Powder


: Positive


Assay(by HPLC)

: 98.0~102.0%



: 465~495


Melting Point

: 191~195


Loss On Drying

: 0.5%max


Specific Rotation

: +288~ +298


Residue On Ignition

: 0.1%max


Related Substances

: Total:1.5%max




Residue Solvents

: 0.2%max


Heavy Metals

: 20PPm max



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