Steroids EstRADiol Cypionate Depofemin Powder

Steroids Estradiol Cypionate Depofemin Powder Product Name: Estradiol Cypionate Synonyms: (17b)-estra-1,3,5(10)-triene-3,17-diol17-cyclopentanepropanoate;(17beta)-Estra-1,3,5(10)-triene-3,17-diol...
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Product Details

Steroids Estradiol Cypionate Depofemin Powder



Product Name: Estradiol Cypionate

Synonyms: (17b)-estra-1,3,5(10)-triene-3,17-diol17-cyclopentanepropanoate;(17beta)-Estra-1,3,5(10)-triene-3,17-diol 17beta-cyclopentanepropanoate;17beta-Estradiol 17-cyclopentylpropionate;17beta-Estradiol cyclopentanepropionate;17beta-Estradiol cypionate;3,5(10)-triene-3,17-diol(17-beta)-estra-17-cyclopentanepropanoate;3,5(10)-triene-3,17-diol(17beta)-estra-17-cyclopentanepropanoate;3-Hydroxyestra-1,3,5(10)-trien-17-yl 3-cyclopentylpropanoate

CAS: 313-06-4

MF: C26H36O3

MW: 396.56

EINECS: 206-237-8


Profiles

1. Estradiol cypionate (INN, USAN; Depo-Estradiol, Depofemin, Estradep, many others), or estradiol cipionate, is a synthetic ester, specifically the 3-cyclopentylpropanoyl ester, of the natural estrogen, estradiol. It was first introduced in 1952 by Upjohn in the United States, and has been in widespread use since. Estradiol cypionate is absorbed more slowly than estradiol itself, and for that reason, it can be administered less often. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate was found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate were found to last for 4-5 days and 7-8 days, respectively.


2. Depofemin is a sex hormone that is present in both males and females, and is the most important form of estrogen in humans. In women, it plays a key role in the development and functioning of the reproductive system, as well as in the growth of certain bones. It also governs the distribution of body fat in women and is the main hormone responsible for the fact that women are shorter than men, on average. Both the ovaries and the adrenal glands produce it.


3. The menstrual cycle in women involves predictable variations in the levels of several hormones, with estradiol being one of them. It is involved in the ovulation process and prepares the inner lining of the uterus for implantation, should the egg be fertilized. Certain tests done on baboons and other primates have indicated that his hormone also plays a continual role in maintaining a pregnancy, helping it to last for the full gestation period.


4. As a sex hormone, it also triggers many of the developments of the reproductive system that begin in puberty. It is present throughout the reproductive years, and declines during and after menopause. This decline is precisely what causes many of the symptoms of menopause, such as hot flashes and night sweats, vaginal dryness, and the loss of bone mass that may lead to osteoporosis.


Usage

Treating certain symptoms of menopause (eg, hot flashes, vaginal itching, burning, or dryness). It is used to treat low levels of estrogen caused by certain conditions.

Estradiol cypionate is a female estrogen hormone. It works by replacing natural estrogens in a woman who can no longer produce enough estrogen.

It is used by women to help reducesymptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vaginashould be considered before medications that are taken by mouth, absorbed through the skin, or injected. This medication may also be used by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).


Certificate of Analysis: 

Product nameEstradiol
AppearanceWhite crystalline powder

Characteristics

White or creamy white, crystalline powder

conform

Melting point

176-180 °C

178~ 179°C

Water

≤3.5%

pass

Assay

97 .0~ 103.0%

99.3%

Loss on drying

≤0.5%

0.1%

Related substances

total impurities ≤1.0%

Pass

any individual impurity ≤0.5%

Pass

Residual solvents

ethanol ≤0.5%

Pass


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