Tibolone Livial 5630-53-5 Powder Oral Estrogen Hormone Prevent Osteoporosis
1, Tibolone Profile:
Product Name: Tibolone
Appearance: White crystalline powder
Melting point: 169 °C
Storage temp.: 2-8°C
Usage: A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
2, Tibolone Key Words:
High purity tibolone powder
Oral Tibolone tablets
Tibolone and SERM
Tibolone, menopause, mood, well-being and sexuality
Symptoms of oestrogen deficiency
To prevent osteoporosis
A man-made female hormone
3, Applications of Tibolone/ Livial:
Tibolone is a 19-nortestosterone derivative and is related structurally to other 19-nortestosterone progestins. It is the 7α-methyl derivative of noretynodrel. It is used mainly for treatment of endometriosis, as well as hormone replacement therapy in post-menopausal women. It has also been investigated as a possible treatment for female sexual dysfunction.
Tibolone has tissue-selective estrogenic effects, with desirable effects in bone, the brain, and the vagina, and lack of undesirable action in the endometrium and breasts. Its tissue selectivity is the result of metabolism, enzyme modulation (e.g., of estrogen sulfatase and estrogen sulfotransferase), and receptor modulation that vary in different target tissues, and differs mechanistically from that of selective estrogen receptor modulators (SERMs) such as tamoxifen, which produce their tissue-selectivity via means of modulation of the ER. As such, to distinguish it from SERMs, tibolone has been described as a "selective tissue estrogenic activity regulator" (STEAR), and also as a "selective estrogen enzyme modulator" (SEEM).
1). Tibolone is a synthetic hormone derived from the Mexican yam.
2). Tibolone is used to replace the body’s natural sex hormones. It is converted in the body into three other substances which act like the hormones oestrogen, progesterone or testosterone in different tissues.
3). Tibolone acts like oestrogen in the brain (preventing flushes), bone (preventing bone loss) and vaginal tissue (preventing dryness and soreness).
4). Tibolone also acts like progesterone in the womb to prevent overgrowth of the endometrium and subsequent bleeding. A woman who has not had a hysterectomy does not need to take a progesterone if she is taking tibolone.
5). Tibolone has testosterone-like activity that appears to play a role in enhancing women’s mood and libido, although response is variable.