Vecuronium bromide CAS 50700-72-6 injection formuscle relaxants
Synonyms: norcuron;1-(3-alpha,17-beta-diacetoxy-2-beta-piperidino-5-alpha-androstan-piperidiniu;17beta-diol,16beta-pipecolinio-2beta-piperidino-5alpha-androstan-3alphbro;mide,diacetate;nc-45;orgnc45;vecuronium;VECURONIUM BROMIDE
Mol File: 50700-72-6.mol
White or almost white powder, odorless, bitter taste, have cited moist. Highly soluble in ethanol, slightly soluble in water, almost insoluble in ether; very soluble in dilute hydrochloric acid.
What is Vecuronium bromide?
Vecuronium bromide, sold under the brand name Norcuron among others, is a medication used as part of general anesthesia to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is also used to help with endotracheal intubation; however, suxamethonium (succinylcholine) is generally preferred if this needs to be done quickly. It is given by injection into a vein. Effects are greatest at about 4 minutes and last for up to an hour.
Side effects may include low blood pressure and prolonged paralysis. Allergic reactions are rare. It is unclear if use in pregnancy is safe for the baby. Vecuronium is in the aminosteroid neuromuscular-blocker family of medications and is of the non-depolarizing type. It works by blocking the action of acetylcholine on skeletal muscles.
vecuronium bromide is one of muscle relaxant most commonly used in liver transplantation. It is metabolized mainly by liver and then discharged in prime type by biliary passage system.
Intermediate-acting non-depolarizing muscle relaxants , strong muscle relaxant effect . Its duration is shorter , faster recovery , and does not cause bronchospasm and decrease in blood pressure , had little effect on the cardiovascular system . For endotracheal intubation and surgery .
How dose Vecuronium bromide works?
Vecuronium operates by competing for the cholinoceptors at the motor end plate thereby exerting its muscle-relaxing properties which are used adjunctively to general anesthesia. Under balanced anesthesia, the time to recovery to 25% of control (clinical duration) is approximately 25 to 40 minutes after injection and recovery is usually 95% complete approximately 45 to 65 minutes after injection of intubating dose. The neuromuscular blocking action of vecuronium is slightly enhanced in the presence of potent inhalation anesthetics. If vecuronium is first administered more than 5 minutes after the start of the inhalation of enflurane, isoflurane, or halothane, or when a steady state has been achieved, the intubating dose of vecuronium may be decreased by approximately 15%.
History of Vecuronium bromide:
As long ago as 1862, adventurer Don Ramon Paez described a Venezuelan poison, guachamaca, which the indigenous peoples used to lace sardines as bait for herons and cranes. If the head and neck of a bird so killed was cut off, the remainder of the flesh could safely be eaten. Paez also described the attempt of a Llanero woman to murder a rival to her lover's affections with guachamaca and unintentionally killed 10 other people when her husband shared his food with their guests. It is probable that the plant was Malouetia nitida or Malouetia schomburgki.
The genus Malouetia (Family Apocynaceae) is found in both South America and Africa. The botanist Robert E. Woodson Jr comprehensively classified the American species of Malouetia in 1935. At that time, only one African species of Malouetia was recognised, but the following year Woodson described a second: Malouetia bequaertiana, from the Belgian Congo.
It was in 1960 that scientists reported the isolation of malouetine from the roots and bark of Malouetia bequaertiana Woodson by means of an ion exchange technique. A pure form of the substance was first synthesised in 1964, and was named pancuronium bromide. The name was derived from p(iperidino)an(drostane)cur(arising)-onium.
A paper published in 1973 discussed the structure-activity relationships of a series of aminosteroid muscle relaxants, including the mono-quaternary analogue of pancuronium, later called vecuronium.
Non-medical use of Vecuronium bromide:
Vecuronium bromide has been used as part of a drug cocktail that prisons in the United States use as a means to put a condemned prisoner to death. Vecuronium is used to paralyze the prisoner and stop his or her breathing, in conjunction with a sedative and potassium chloride to stop the prisoner's heart. Injections of vecuronium bromide without proper sedation allow the person to be fully awake but unable to move in response to pain.
In 2001, Japanese nurse Daisuke Mori was reported to have murdered 10 patients using vecuronium bromide. He was convicted of murder and was sentenced to life imprisonment.
COA of Vecuronium bromide:
White, yellowish-white or slightly pink crystalline powder
White crystalline powder
1) The IR absorption spectrum of the sample is concordant with that of Pancuronium Bromide standard
2) It gives reaction of bromides
Specific optical rotation
Appearance of solution
Clear and colourless
Related Substances (TLC)
Impurity A NMT 1.0%
Impurity D NMT 1.0%
any other impurities NMT 0.1%
Conclusion: It conforms to the EP STANDARD.
Adjuvant is mainly used for surgical anesthesia,Pregnant women and children should not be used.
Alpha GPC(Choline Alfoscerato)
Tianeptine sodium salt
Tianeptine free acid
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