Bodybuilding Prohormones Prostaglandin Misoprostol

Oral Anabolic Steroids Misoprostol CAS 59122-46-2 Ulcer prevention Failed miscarriage Postpartum Misoprostol Quick Details: CAS No.:84371-65-3 Other Names:Misoprostol MF:C29H35NO2 Place of Origin:ShenZhen, China (Mainland)...
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Oral Anabolic Steroids Misoprostol CAS 59122-46-2 Ulcer prevention Failed miscarriage Postpartum



Quick Details:

CAS No.:84371-65-3

Other Names:Misoprostol

MF:C29H35NO2

Place of Origin:ShenZhen, China (Mainland)

Type:Antineoplastic Agents, Vitamins, Amino Acids and Coenzymes

Grade Standard:Medicine Grade

Brand Name: SENDI

Model Number:Top Grade

Purity:99.9%

Product Name:Mifepristone

Certificate:ISO9001

Specification:99% HPLC

Stock:Available

Grade::Medicine Grade

COA:Available

Storage:Cool Dry Place

test Method:HPLC

MOQ:1G

Color:White Powder

Use:

Misoprostol is approved for use in the prevention of NSAID-induced gastric ulcers. It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell. Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors, are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the elderly and people with ulcer complications. Misoprostol is sometimes coprescribed with NSAIDs to prevent their common adverse effect of gastric ulceration (e.g. with diclofenac in Arthrotec).
Misoprostol has other protective actions, but is only clinically effective at doses high enough to reduce gastric acid secretion. For instance, at lower doses, misoprostol may stimulate increased secretion of the protective mucus that lines the gastrointestinal tract and increase mucosal blood flow, thereby increasing mucosal integrity. However, these effects are not pronounced enough to warrant prescription of misoprostol at doses lower than those needed to achieve gastric acid suppression.
However, even in the treatment of NSAID-induced ulcers, omeprazole proved to be at least as effective as misoprostol,but was significantly better tolerated, so misoprostol should not be considered a first-line treatment. Misoprostol-induced diarrhea and the need for multiple daily doses (typically four) are the main issues impairing compliance with therapy.

Applications:
The most commonly reported adverse effect of taking a misoprostol orally for the prevention of stomach ulcers is diarrhea. In clinical trials, an average 13% of patients reported diarrhea, which was dose-related and usually developed early in the course of therapy (after 13 days) and was usually self-limiting (often resolving within 8 days), but sometimes (in 2% of patients) required discontinuation of misoprostol.
 
The next most commonly reported adverse effects of taking misoprostol orally for the prevention of gastric ulcers are: abdominal pain, nausea, flatulence, headache, dyspepsia, vomiting, and constipation, but none of these adverse effects occurred significantly more often than when taking placebos. In practice, fever is almost universal when multiple doses are given every 4 to 6 hours.
 
Misoprostol should not be taken by pregnant women to reduce the risk of NSAID-induced gastric ulcers because it increases uterine tone and contractions in pregnancy, which may cause partial or complete abortions, and because its use in pregnancy has been associated with birth defects.

Description:
Misoprostol is a medication used to start labor, induce abortions, prevent and treat stomach ulcers, and treat postpartum bleeding due to insufficient contraction of the uterus. For abortions it is used with mifepristone or methotrexate. It is a synthetic prostaglandin E1 (PGE1).
 
Common side effects include diarrhea and abdominal pain. It is pregnancy category X meaning that it is known to result in negative fetal outcomes if taken during pregnancy. Uterine rupture may occur.
 
It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. Misoprostol was invented and marketed by G.D. Searle & Company under the trade name Cytotec, but other trade names and generic formulations are available.

Specification


ItemsSpecificationResults
CharacteristicsWhite to off-white powderConfirms
IdentificationHPLC & UV confirms to standardConfirms
SolubilityClearConfirms
Water, %≤5.01.81
Individual impurities, %
A-type misoprostol≤0.300.14
B-type miprostol≤0.30N.D.
Norsoprostol≤0.10N.D.
8-epimisoprostol≤0.300.08
12-epimisoprostol≤1.00.24
Any other single impurity≤0.500.07
Total impurities, %≤2.00.53
Residue on Ignition, %≤1.500.56
Heavy metals, ppm≤10.0Confirms
Assay, %0.9~1.101.05


Gastric and duodenal ulcers

Misoprostol is approved as a finished medicinal product for the prevention and treatment of drug-related mucosal damage or ulcers of the stomach and duodenum, which may arise when taking nonsteroidal anti-inflammatory drugs and their administration can neither be discontinued nor the dose can be reduced. 


Because of the effect on the uterine musculature an application may only be made if pregnancy is excluded. Misoprostol must not be taken during breast-feeding as it passes into breast milk.

Danger of abuse was that pregnant women under the pretext of gastric complaints due to use of painkillers could be prescribed by their family doctor Misoprostol, the funds then, however, took the illegal abortion.


Gynecology, Obstetrics 

Further fields of application are in gynecology and obstetrics. After birth, misoprostol is used to treat bleeding complications. In addition, it is used to induce labor, to trigger a muted abortion and to support medical abortion in the first and second trimesters (trimester) of pregnancy. A medical abortion occurs through the medical administration of mifepristone, two days later Misoprostol is given.


Because of these important indications, the drug is on the WHO list of essential medicines. However, it is criticized that it is not listed in this list for bleeding complications after birth, although this method is relatively easy to apply even in remote areas. For gynecological or obstetrical applications, misoprostol-containing finished medicinal products are only approved in a limited number of countries, [8] therefore the application is largely in off-label use, including in Germany. Misoprostol is the only prostaglandin that can be administered orally in these indications.


Trigeminal Neuralgia 

In a small, open study, misoprostol has been shown to be effective in the treatment of refractory trigeminal neuralgia in patients with multiple sclerosis. 


Side effects 

In the treatment of ulcers, diarrhea, which occurs in 13% of cases, leads to a total discontinuation of therapy at 0.5%.


It can also cause nausea and abdominal pain as well as headache and dizziness.  Cardiovascular effects are virtually nonexistent

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