Place of Origin:ShenZhen, China (Mainland)
Type:Antineoplastic Agents, Vitamins, Amino Acids and Coenzymes
Grade Standard:Medicine Grade
Brand Name: SENDI
Model Number:Top Grade
Storage:Cool Dry Place
Misoprostol is a medication used to start labor, induce abortions, prevent and treat stomach ulcers, and treat postpartum bleeding due to insufficient contraction of the uterus. For abortions it is used with mifepristone or methotrexate. It is a synthetic prostaglandin E1 (PGE1).
Common side effects include diarrhea and abdominal pain. It is pregnancy category X meaning that it is known to result in negative fetal outcomes if taken during pregnancy. Uterine rupture may occur.
It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. Misoprostol was invented and marketed by G.D. Searle & Company under the trade name Cytotec, but other trade names and generic formulations are available.
|Characteristics||White to off-white powder||Confirms|
|Identification||HPLC & UV confirms to standard||Confirms|
|Individual impurities, %|
|Any other single impurity||≤0.50||0.07|
|Total impurities, %||≤2.0||0.53|
|Residue on Ignition, %||≤1.50||0.56|
|Heavy metals, ppm||≤10.0||Confirms|
Gastric and duodenal ulcers
Misoprostol is approved as a finished medicinal product for the prevention and treatment of drug-related mucosal damage or ulcers of the stomach and duodenum, which may arise when taking nonsteroidal anti-inflammatory drugs and their administration can neither be discontinued nor the dose can be reduced.
Because of the effect on the uterine musculature an application may only be made if pregnancy is excluded. Misoprostol must not be taken during breast-feeding as it passes into breast milk.
Danger of abuse was that pregnant women under the pretext of gastric complaints due to use of painkillers could be prescribed by their family doctor Misoprostol, the funds then, however, took the illegal abortion.
Further fields of application are in gynecology and obstetrics. After birth, misoprostol is used to treat bleeding complications. In addition, it is used to induce labor, to trigger a muted abortion and to support medical abortion in the first and second trimesters (trimester) of pregnancy. A medical abortion occurs through the medical administration of mifepristone, two days later Misoprostol is given.
Because of these important indications, the drug is on the WHO list of essential medicines. However, it is criticized that it is not listed in this list for bleeding complications after birth, although this method is relatively easy to apply even in remote areas. For gynecological or obstetrical applications, misoprostol-containing finished medicinal products are only approved in a limited number of countries,  therefore the application is largely in off-label use, including in Germany. Misoprostol is the only prostaglandin that can be administered orally in these indications.
In a small, open study, misoprostol has been shown to be effective in the treatment of refractory trigeminal neuralgia in patients with multiple sclerosis.
In the treatment of ulcers, diarrhea, which occurs in 13% of cases, leads to a total discontinuation of therapy at 0.5%.
It can also cause nausea and abdominal pain as well as headache and dizziness. Cardiovascular effects are virtually nonexistent