Norethisterone Female Sex Hormones

Female Sex Hormones Crystalline Powder Mifepristone CAS 68-22-4 Norethisterone Norethisterone Quick Details: CAS No.:68-22-4 Other Names:Norethisterone MF:C20H26O2 EINECS No.:200-681-6 Place of Origin:ShenZhen, China (Mainland)...
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Product Details

Female Sex Hormones Crystalline Powder Mifepristone CAS 68-22-4 Norethisterone 


Norethisterone 

Quick Details:

CAS No.:68-22-4

Other Names:Norethisterone

MF:C20H26O2

EINECS No.:200-681-6

Place of Origin:ShenZhen, China (Mainland)

Type:Antibiotic and Antimicrobial Agents, Antineoplastic Agents, Antiparasitic Agents, Antipyretic Analgesics and NSAIDs, Auxiliaries and Other Medicinal Chemicals

Grade Standard:Medicine Grade

Brand Name:SENDI

Model Number:Top Grade

Purity:99%min

MW:298.42

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Description:

Norethindrone is used to treat endometriosis, a condition in which the type of tissue that lines the uterus (womb) grows in other areas of the body and causes pain, heavy or irregular menstruation (periods), and other symptoms. Norethindrone is also used to treat abnormal periods or bleeding and to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 6 months and who are not pregnant or undergoing menopause (change of life). Norethindrone is also used as a test to see if the body is producing certain female hormones (natural substances that affect the uterus). Norethindrone is in a class of medications called progestins. It works by stopping the lining of the uterus from growing and by causing the uterus to produce certain hormones.

 

Medical uses:

NET is used as a hormonal contraceptive in combination with an estrogen - usually ethinylestradiol (EE) - in combined oral contraceptive pills and alone in progestogen-only pills. Aside from its use as a contraceptive, NET can be used to treat premenstrual syndrome, dysmenorrhea, menorrhagia, irregular menstruation, menopausal symptoms (in combination with estrogen), or to postpone a period. It is also commonly used to help prevent uterine hemorrhage in complicated non-surgical or pre-surgical gynecologic cases and in treating non responsive cyclical mastalgia.

 


How to Use Norethindrone?

Oral Tablet
Take this medicine by mouth with a glass of water. You may take it with or without food. Follow the directions on the prescription label. Take this medicine at the same time each day and in the order directed on the package. Do not take your medicine more often than directed.

Contact your pediatrician regarding the use of this medicine in children. Special care may be needed. This medicine has been used in female children who have started having menstrual periods.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.


History

Norethisterone was the first orally active synthetic progestogen. It was first synthesized in 1951 by Carl Djerassi, Luis E. Miramontes and George Rosenkranz at Syntex in Mexico City. 


In addition to its use in contraception Norethisterone was used in high doses in combination with ethinylestradiol until 1973 under the brand name Duogynon and until 1980 under the name Cumorit as a pregnancy test and for the treatment of menstrual disorders.


Duogynon Scandal 

Schering sold until 1973 in Germany under the brand name Duogynon and until 1980 under the name Cumorit drugs for the treatment of menstrual disorders and as a pregnancy test. Duogynon, taken in early pregnancy , was associated with an accumulation of malformed children in the 1970s. There are supposedly 1000 cases in Germany alone. In 2010, a suspected injured party in broad media interest filed an action for access to the file against the manufacturer Schering, which was dismissed on January 11, 2011 for limitation. [7] Even with one in November 2011 on behalf of hundreds of victims filed liability claim against Schering failed the plaintiff. The lawsuit was also dismissed for prescription. 


In August 2012, the plaintiff accused the Berlin district court of not having followed up references to a presumed influence on research results by employees of the Schering Group. A former Schering employee allegedly admitted to the plaintiff that he had bribed scientists at the beginning of the 1980s in order to make Duogynon appear positive in a brochure. In the room there were payments of 100,000 marks. At that time, the risk of malformations had been known for over a decade and corresponding preparations of competing companies had long since been withdrawn from the market. 


The Federal Institute for Drugs and Medical Devices and the Paul Ehrlich Institute published in the Bulletin on Drug Safety in December 2012, that the previously published studies on Duogynon and other estrogen-progestin preparations have no evidence of specific teratogenic effects (teratogenic) in pregnancy Offer. A teratogenic or embryotoxic effect of Duogynon, for any purpose whatsoever, is considered unlikely in the report.


However, on the other hand documents have emerged, which prove that employees of the English Schering headquarters then warned the colleagues in Germany. They recommended removing Duogynon from the market. A former Schering employee is now willing to put these internal doubts in court on record. After the trial files stored in the state archives in Berlin in 2016 were revealed, which showed that even leading Schering employees did not rule out a causal connection between the use of Duogynon and the malformations, the case went on trial again in Germany. In June 2016, a murder complaint was filed on behalf of the mother of an affected child. Murder is a crime that does not expire.

Attention:


Do NOT use norethindrone if:
you are allergic to any ingredient in norethindrone
you are pregnant or think you may be pregnant
you have undiagnosed abnormal vaginal bleeding or are postmenopausal
you have a history of blood clotting problems, severe blood clots (eg, in the lungs, legs, eyes), certain blood vessel problems (eg, bleeding in the brain, heart attack, stroke), or breast cancer
you have decreased liver function or active liver disease
Contact your doctor or health care provider right away if any of these apply to you.
 

Side Effects:

Nausea, vomiting, headache, bloating, breast tenderness, or weight gain may occur. Vaginal bleeding between periods (spotting) or missed/irregular periods may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If you miss 2 periods in a row (or 1 period if the pill has not been used properly), contact your doctor for a pregnancy test.
 

COA:

Analysis tests

Standard

Results

Appearance

White or kind of white powder or crystalline powder

Almost white crystalline powder

Specific rotation

-32.0º~ -37º

-35.4º

Identification

Positive reaction

Conforms

IR Pattern consistent with the spectral set

Conforms

Melting range

202.0-208.0℃

202.5-207.5℃

Loss on drying

≤0.5%

0.1%

Related substance

Total impurities ≤1.5%

0.86%

Assay

99-102.0%

99.9%

Conclusion

Meets the specification of CP2015


Other Estrogen Product list:

 

Product nameCAS number
Ethisterone434-03-7
Norethisterone68-22-4
Ethinylestradiol57-63-6
Ethynodiol diacetate297-76-7
Chlormadinone acetate302-22-7
Cyproterone acetate427-51-0
Megestrol acetate595-33-5
Estradiol50-28-2
17alpha-Oestradiol57-91-0
Estradiol enantate4956-37-0
Estradiol valerate979-32-8
Estradiol Benzoatae50-50-0
Estrone53-16-7
Estriol50-27-1
19-Norethindrone acetate51-98-9
Norethisterone enanthate3836-23-5
Testolactone968-93-4
Eplerenone107724-20-9
Canrenone976-71-6
Formestane566-48-3
Drospirenone67392-87-4
Algestone acetophenide24356-94-3
Dehydronandrolone Acetate2590-41-2
Progesterone57-83-0
Medroxyprogesterone Acetate71-58-9
Pregnenolone145-13-1
Allylestrenol432-60-0
Melengestrol Acetate2919-66-6
Eplerenone107724-20-9
Dienogestrel65928-58-7
Mifepristone84371-65-3
Ethisterone434-03-7
Levonorgestrel797-63-7
Clomifene citrate50-41-9
Diethylstilbestrol56-53-1
Pregnenolone acetate1778-02-5

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