High purity Ethinylestradiol or 17-Ethinylestradiol CAS 57-63-6 Pharmaceutical Ethynyl Estradiol Treating Female Hypogonadism
Place of Origin:ShenZhen, China (Mainland)
Type:Auxiliaries and Other Medicinal Chemicals
Grade Standard:Medicine Grade
Usage: Treating Female Hypogonadism
Brand Name: SENDI
Shelf life:2 Years
Ethinyl estradiol (EE), also sometimes written as ethinylestradiol, ethynyl
Ethinylestradiol, like estradiol, acts as an agonist on the estrogen receptors inside the cell. In particular, the additional ethynyl group at C-17 influences its pharmacokinetic properties. For example, ethinylestradiol undergoes a markedly reduced first-pass effect in the liver compared to estradiol, resulting in significantly increased oral bioavailability.
Areas of application (indications)
Ethinyl estradiol is mainly used for contraception and, together with a progestogen, it is a typical ingredient of combined oral contraceptives (birth control pills). Other applications include hormone replacement therapy, palliative treatment for prostate cancer and various menstrual disorders, such as primary and secondary amenorrhea.
In a typical contraceptive pill, the daily ethinylestradiol dose is 20 to 35 micrograms today.  Dosages of 50 to 100 micrograms were common in the 1960s.
Ethinylestradiol-containing preparations should not be used for the following diseases - acute or even in the past - (selection):
Diseases of the liver, in particular liver tumors
Estrogen-dependent tumors of uterus and mammary gland
difficult to treat hypertriglyceridemia
unexplained vaginal bleeding
Difficult to adjust arterial hypertension (high blood pressure)
Diabetes mellitus with vascular changes
Migraines with focal neurological symptoms
Use during pregnancy and lactation
There is no indication for the use of ethinylestradiol in pregnancy. While breast-feeding, it should be noted that ethinyl estradiol may enter breast milk and also reduce its formation.
Ethinylestradiol is a man-made form of the naturally occurring female hormone called oestrogen. It is prescribed to treat period (menstrual) problems, and also to help ease menopausal symptoms. It is usually prescribed alongside another female hormone called a progestogen.
Ethinyl estradiol also sometimes written as ethinylestradiol, ethynyl estradiol, or ethinyl? Stradiol, is a derivative of 17β -estradiol (E2), the major endogenous estrogen in humans. EE is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills. It is one of the most commonly used medications for this purpose.
Estinyl was a preparation of EE alone that was used for the management of menopausal symptoms and female hypogonadism.
EE is released into the environment as a xenoestrogen from the urine and feces of people who take it as a medication.
Ethinyl estradiol (EE2), also sometimes written as 17α -ethinyl estradiol, ethinylestradiol, ethynyl estradiol, or ethinyl? Stradiol, is a derivative of 17β -estradiol (E2), the major endogenous estrogen in humans. EE2 is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills. It is one of the most commonly used medications for this purpose.
Ethinyl Estradiol and its metabolites are excreted with the bile. Due to the effect of entero hepatic circulation a second peak is seen several hours later. Individually, wide variations exist in the overall absorption process, and can be further modified by drugs that affect the enterohepatic circulation or liver enzymes.
In circulation Ethinyl Estradiol is almost fully bound to plasma albumin. It is metabolized by hydroxylation of the aromatic ring and excreted in both feces and urine, in part as glucuronide and sulfate conjugate.
Ethinyl Estradiol is hormonally effective by activating the estrogen receptor and thus is an estrogen. It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives. Over time, formulations have decreased the Ethinyl Estradiol dose from as high as 100 μg to as low as 10 μg.
Interactions with other medications
Due to its pharmacokinetic properties, ethinylestradiol undergoes multiple drug interactions. In the first place are interactions with enzyme inducers of the cytochrome P450 enzyme system. Ethinyl estradiol is v. a. metabolised by CYP3A4 in the liver. Various drugs for the treatment of epilepsy (anticonvulsants) such as barbiturates, carbamazepine, phenytoin or primidone, but also the anti-infective rifampicin or the herbal antidepressant St. John's wort intensify the expression of this enzyme, thus increasing the metabolism of ethinylestradiol, and reduce - when used as part of birth control pills - the contraceptive effect.
Ethinylestradiol is partially subject to an enterohepatic cycle. Glucuronic or sulphate conjugates enter the intestine with bile. There they are partially split by the intestinal flora, the unbound ethinylestradiol can be absorbed again and work longer. Decreased ethinylestradiol plasma levels have been observed with concomitant use of birth control pills with tetracyclines and various penicillins. It is unclear whether this is actually due to impaired enterohepatic circulation.
Adverse effects (side effects)
The most common side effects after taking ethinyl estradiol (in oral contraceptives) include chest pain and increased breast sensitivity, weight changes, acne, mood swings, and vaginitis. Occasionally there are changes in the appetite, abdominal cramps or rash. By observing the contraindications, the occurrence of the most serious side effects such as thromboembolism and cancers of the liver, cervix and mammary gland should be minimized.