Finasteride Prostide Sexual And Hair Loss Treatment

High purity chemicals product Finasteride Prostide Powder BodyBuilding Sexual and Hair Loss Treatment Drug CAS 98319-26-7 low price and best quality Finasteride Quick Details: CAS No.:98319-26-7 Other Names:Finasteride MF:C23H36N2O2...
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High purity chemicals product Finasteride Prostide Powder BodyBuilding Sexual and Hair Loss Treatment Drug CAS 98319-26-7 low price and best quality


Finasteride 

Quick Details:

Product Name:Finasteride Powder

CAS No.:98319-26-7

Other Names:Finasteride, Proscar;

MF:C23H36N2O2

Place of Origin:ShenZhen, China (Mainland)

Type:Cardiovascular Agents

Grade Standard: Medicine Grade

Usage: Anti-hairloss

Brand Name:SENDI

Model Number:SENDI-Finasteride Powder

Purity:99%min

Appearance:White powder

Melting point:257℃

Specific rotation:50.0°~ -60.0°

Test Method:HPLC

Molecular Weight:372.54g/mol

Solubility in water:Insoluble


Applications:

Finasteride is an antiandrogen which acts by inhibiting type II 5-alpha reductase.It is used as a treatment in benign prostatic hyperplasia (BPH) in low doses, and prostate cancer in higher doses. It is also indicated for use in combination with doxazosin therapy to reduce the risk for symptomatic progression of BPH. Additionally, it is registered in many countries for androgenetic alopecia (male-pattern baldness).
 
Finasteride was approved initially in 1992, a treatment for prostate enlargement, but the sponsor had studied 1 mg of finasterideand demonstrated hair growth in male pattern hair loss. On December 22, 1997, the FDA approved finasteride to treat male pattern hair loss.


Usages:

1) Used for treatment of hair loss;

2) For the treatment of benign prostatic hyperplasia, enlarged prostate shrink, improve urinary flow and improvement of benign prostatic hyperplasia caused symptoms.

 

Benign prostatic hyperplasia

Physicians use finasteride for the treatment of BPH, informally known as an enlarged prostate. The FDA-approved dose is 5 mg once a day. Six months or more of treatment with finasteride may be required to determine the therapeutic results of treatment.  If the drug is discontinued, any therapeutic benefits reverse within about –8 months. Finasteride may improve the symptoms associated with BPH such as  difficulty urinating, getting up during the night to urinate, hesitation at the start of urination, and decreased urinary flow.

 

Male pattern baldness

Finasteride is used to treat male pattern hair loss (androgenetic alopecia) in men only. Treatment provides about 30% improvement in hair loss after six months of treatment,  and effectiveness only persists as long as the drug is taken.

 

Off-label uses

Finasteride is sometimes used in hormone replacement therapy for male-to-female transsexuals in combination with a form of estrogen due to its antiandrogen properties. However, little clinical research of finasteride use for this purpose has been conducted and  evidence of efficacy is limited.

Finasteride / Prostide COA:

Test ItemsSpecificationTest Results
DescriptionWhite or off-white crystalline powderOff-white crystalline powder
Specific rotation-56°~-60°-58.2°
IdentificationIRMatches with working standard
Complies
HPLC


SolubilityFreely soluble in chloroform and in alcohol;
Very slightly soluble in water
Conform
Heavy metals≤10ppm<10ppm
Water≤0.3%0.22%
Residue on ignition≤0.1%0.05%
Relative materialMaximum impurities≤0.5%0.36%
Total impurities≤1.0%0.52%
Assay99~101.0%99.99%
ConclusionThe specification conform with Enterprise standard

What is Finasteride?
Medical uses
(1) Benign prostatic hyperplasia
Physicians use finasteride for the treatment of benign prostatic hyperplasia (BPH), informally known as an enlarged prostate. The FDA-approved dose is 5 mg once a day. Six months or more of treatment with finasteride may be required to determine the therapeutic results of treatment. If the drug is discontinued, any therapeutic benefits reverse within about 6-8 months. Finasteride may improve the symptoms associated with BPH such as difficulty urinating, getting up during the night to urinate, hesitation at the start of urination, and decreased urinary flow.

(2) Male pattern baldness
Three Phase 3 clinical trials examined the efficacy of finasteride in the treatment of mild to moderate male pattern baldness. The primary endpoints of each trial were hair count and user self-assessment. Secondary endpoints included investigator assessment and examination of scalp photographs. Each patient also filled out questionairres regarding sexual health and non-scalp body hair growth. These trials enrolled 1879 men and had a duration of one year. Of these 1879 men, 1215 elected to participate in a one year double blind extension trial. Additional extension trials were performed such that 323 men experienced over 4 years of treatmentFinasteride / Prostide Applications:

Propecia (finasteride) is used to treat male pattern baldness (androgenic alopecia) in men. Oral use though will reduce DHT levels systemically, which may adversely affect training and sexual. It is also used in combination with doxazosin in the treatment of benign prostatic hyperplasia (BPH).
Finasteride is an orally active testosteron Type II 5-alpha reductase inhibitor,inhibiting the enzyme that converts testosteron to dihydrotestosteron (DHT).
Topically (on the scalp itself) it is of some effect in minimizing further hair loss. In combination with Nizoral (which smells awful, by the way) it can actually reverse loss moderately.
For use in cycles with testosteron, I don't think it is bad at all. One simply doesn't want less DHT than normal. As the amount of testosteron in the system increases, the amount of finasteride needed to keep levels down to normal increases. I consider 5 mg/day reasonable at the gram per week level, and proportionally less at lower dosages of testosteron.

Mode of action:

Finasteride is a 5α-reductase inhibitor and belongs to the synthetic steroids. By its similarity [14] to natural testosterone, it irreversibly blocks 5α-reductase, thus preventing the conversion of the sex hormone testosterone to dihydrotestosterone (DHT). According to the current state of knowledge of research, certain hair follicles respond to DHT by reducing the anagen phase (growth phase). This sensitivity of hair follicles is hereditary. Finasteride inhibits the conversion of testosterone into DHT. The hair follicles can then react with an extension of the anagen phase. However, if the hair follicle is barely active, usually nothing can be achieved. Finasteride must be taken as long as the man wants to keep his hair. As a result, finasteride shifts the onset of man's androgenetic hair loss in later years. If the treatment is interrupted, the DHT level in the blood increases and also the regrown hair follicles can fail again. First successes can only be observed after a period of use of 3-6 months.


The response to finasteride therapy (stopping hair loss, stimulating new hair growth) may be related to up-regulation of IGF1. In a small study of 9 subjects, the efficacy of finasteride in some individuals correlated with the up-regulation of IGF1.  Also, androgen receptor polymorphism appears to be important for response to therapy. 


The androgen receptor exists in two forms (A-form and B-form), which differ in their activity. The A-form is smaller than the B-form with 110kDa at 87kDa (the first 187 amino acids are missing by proteolysis). Normally, about 80% of the total receptor amount is in the B form and only 20% is in the A form. [19] [20] There is evidence that androgenetic alopecia is associated with transformation of the B-form into the A-form and that primarily the A-form is responsible for the AGA via stimulation by DHT. While there is a normal A / B ratio (more receptors in B-form) at the back of the head in androgenetic alopecia patients, there are more receptors in the A-form in bald regions. Finasteride is expected to return the A / B ratio to normal again by inverse transformation of the A-form to B-form receptors, which may be related to efficacy.

Over the course of several years of international studies, 80 to 90% of users were able to stop the onset of hair loss, and in about 65% even head hair thickening was achieved by thickening previously shrunken hair. Contrary to previous assumptions, a 2003 study showed that finasteride also has a significant effect on users between the ages of 41 and 60 years.

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