Megestrol Acetate For Acting Contraceptives

High Purity 99% Progesterone Acetate Megestrol MGA / CAS 595-33-5 for Acting Oral Contraceptives Brief Introduction : Product Name:Megestrol Acetate CAS NO.: 595-33-5 EINECS: 209-864-5 Assay: 99% Molecular Formula:C24H32O4 Molecular...
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  High Purity 99% Progesterone Acetate Megestrol MGA / CAS 595-33-5 for Acting Oral Contraceptives


Brief Introduction :
 Product Name:Megestrol Acetate
CAS NO.: 595-33-5
EINECS: 209-864-5
Assay: 99%
Molecular Formula:C24H32O4
Molecular Weight:384.51
Manufacturer:china
Appearance: White or light yellow crystalline powder (methanol), odorless and tasteless. Melting point 214-216. Soluble in acetone, slightly soluble in ethanol, insoluble in water.


Description:

Megestrol acetate (INN, USAN, BAN, JAN; sold mainly under the brand names Megace and Megace ES), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, and sometimes abbreviated as MGA or MA, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.
Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound.

Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers. When given in relatively high doses, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia. It is also used as a contraceptive in combination with an estrogen at relatively low doses.

Megestrol acetate has powerful antiandrogenic and antiestrogenic effects in humans at sufficient doses, capable of decreasing circulating androgen and estrogen concentrations to castrate levels in both sexes and significantly lowering the expression of the androgen receptor (AR) and the estrogen receptor (ER) in the body.


Application:

Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers. When given in relatively high doses, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia. It is also used as a contraceptive in combination with an estrogen at relatively low doses.
In addition to its use in humans, megestrol acetate has been used extensively in veterinary medicine in the treatment of medical conditions in cats and dogs.
 
Usage:

Megestrol acetate is available as 5 mg, 20 mg and 40 mg tablets and in oral suspensions of 125 mg/ml and 40 mg/ml. It is used at a dose of 5 mg in combination with an estrogen for contraception. Appetite stimulation is achieved with doses ranging from 400 mg to 800 mg a day. Doses used to treat cancer usually range from 40 mg to 320 mg.


Deferred products:

  (1) Megestrol acetate tablets (2) Megestrol acetate dispersible tablets (3) Megestrol acetate capsules
Application: Palliative treatment for advanced breast and endometrial cancers

Dosage:

  Tablet Breast Cancer 160mg/day, once or in divided doses. Endometrial cancer 40-320mg/day, once or in fractions. It is not recommended to apply within the first four months of pregnancy. Patients with a history of thrombophlebitis should be used with caution. Stop breastfeeding during
treatment.


Megestrol Acetate Certificate of Analysis

Test Items Specification Test Results
AppearanceWhite to creamy white 
crystalline powder
White crystalline powder
IdentificationIRComplies
Completeness 
of solution
Meets the requirements.
500mg being 
Complies
 
Solubility

 
dissolved in 10ml of 
acetone
 
Complies

 
Insoluble in water, sparingly 
soluble in 
alcohol. Slightly soluble in 
ether and in 
fixed oils, soluble in acetone; 
very soluble
in chloroform.
Melting range213ºC~220ºC 217ºC
Specific optical rotation+8.8°~ +12.0°+11.6°
Water≤0.5%0.1%
Residue roration≤0.2%0.06
Heavy metals≤0.002%Complies
Assay99.0%~103.0%99.9%
Residual solvents
 
Methanol≤1000ppm74ppm
Ethanol≤1000ppm39ppm
Methylene chloride≤500ppm28ppm
Tetrahydrofuran≤300ppmND
Benzene≤2ppmND
ConclusionComplies

IMG_20160508_145340_副本


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