Buy Raw Progestin Progesterone Megestrol Acetate (MGA) Powder Online CAS 3562-63-8
Place of Origin:ShenZhen, China (Mainland)
Type:Endocrine System Agents
Grade Standard:Medicine Grade
Sulfated ash:0.2% Max.
Heavy metal:10ppm Max
Total Impurity:0.5% Max.
Certification:ISO 9001 COA MSDS
Megestrol acetate (MGA) (INN, USAN, BAN, JAN) (brand names Megace, Megace ES), also known as 17-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin of the 17-hydroxyprogesterone group that is used in the treatment of breast and endometrial cancer and as an appetite stimulant. It is the 17-acetate ester of megestrol, which, in contrast to MGA, was never marketed for clinical use. The term megestrol is often inappropriately used as a synonym for MGA, and when it is used, it almost always refers to MGA rather actually than megestrol.
MGA is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers.When given in relatively high doses, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia. It is also used as a contraceptive in combination with an estrogen at relatively low doses.
In addition to its use in humans, MGA has been used extensively in veterinary medicine in the treatment of medical conditions in cats and dogs.
White or yellowish crystalline powder (methanol), odorless, tasteless. Melting point 214-216. Soluble in acetone, slightly soluble in ethanol, ether, insoluble in water. Intermediates of medroxyprogesterone acetate (medroxyprogesterone). The available 16,17 alpha epoxy progesterone by bromination debromination and nickel hydrogen open-loop catalytic reduction, generating 17 alpha hydroxy progesterone, followed by acetylation and acid hydrolysis of 17 alpha acetoxy ketone, then by etherification and Vilsmeier reaction of ethyl formate three 3- ethyoxyl -6- formyl -17 A-acetyl oxy pregnane -2,5- diene -20- ketone, finally using potassium borohydride reduction, acid hydrolysis, dehydration and translocation to prepare the goods.
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