Mometasone Furoate Steroids Hormone Drugs (CAS 83919-23-7)
Product Name:Mometasone furoate
Synonyms:SCH-32088;MOMETASONE 17-FUROATE;MOMETASONE FUROATE;NASONEX;(11-beta,16-alpha)-xy-16-methyl;pregna-1,4-diene-3,20-dione,9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydro;9-chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one furoate;(11BETA,16ALPHA)-9,21-DICHLORO-17-[(2-FURANYLCARBONYL)OXY]-11-HYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
Melting point 218-220°C
alpha D26 +58.3° (dioxane)
storage temp. Store at -20°C
solubility DMSO: ≥20mg/mL
color white to off-white
Chemical PropertiesWhite-to-Off-White Solid
UsesA topical corticosteroid used as an anti-inflammatory
UsesAn anti-inflammatory agent
UsesA deuterated topical corticosteroid used as an anti-inflammatory.;Labeled Mometasone, intended for use as an internal standard for the quantification of Mometasone by GC- or LC-mass spectrometry.
Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis) (topical form), allergic rhinitis (such as hay fever) (topical form), asthma (inhalation form) for patients unresponsive to less potent corticosteroids, and penile phimosis. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.
Some low-quality evidence suggests the use of mometasone for symptomatic improvement in children with adenoid hypertrophy.
Mometasone is used to alleviate inflammation and itchiness in skin conditions that respond to treatment with glucocorticoids such as psoriasis and atopic dermatitis.
Nasal mometasone is used in adults (including the elderly) and children over two years of age, to diminish the symptoms such as hay fever (seasonal allergic rhinitis) and other allergies (perennial rhinitis), including nasal congestion, discharge, pruritus, and sneezing and to treat nasal polyps.
Items of analysis
White to off-white powder
+56 －+62 °
Loss on drying
Residue On Ignition
Mometasone furoate reduces inflammation by causing several effects:
Reversing the activation of inflammatory proteins
Activating the secretion of anti-inflammatory proteins
Stabilizing cell membranes
Decreasing the influx of inflammatory cells
In addition to the glucocorticoid properties of mometasone furoate, it is a very potent agonist of the progesterone receptor as well as a partial agonist of the mineralocorticoid receptor.