Mometasone Furoate Steroids Hormone Drugs (CAS 83919-23-7)

Mometasone Furoate Steroids Hormone Drugs (CAS 83919-23-7) Product Name: Mometasone furoate Synonyms: SCH-32088;MOMETASONE 17-FUROATE;MOMETASONE...
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Product Details

Mometasone Furoate Steroids Hormone Drugs (CAS 83919-23-7)



Product Name:Mometasone furoate

Synonyms:SCH-32088;MOMETASONE 17-FUROATE;MOMETASONE FUROATE;NASONEX;(11-beta,16-alpha)-xy-16-methyl;pregna-1,4-diene-3,20-dione,9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydro;9-chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one furoate;(11BETA,16ALPHA)-9,21-DICHLORO-17-[(2-FURANYLCARBONYL)OXY]-11-HYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE

CAS:83919-23-7

MF:C32H32Cl2O8

MW:615.5

EINECS:1308068-626-2

Mometasone furoate Structure


Properties

Melting point 218-220°C

alpha D26 +58.3° (dioxane)

storage temp. Store at -20°C

solubility DMSO: ≥20mg/mL

color white to off-white

Chemical PropertiesWhite-to-Off-White Solid

UsesA topical corticosteroid used as an anti-inflammatory

UsesAn anti-inflammatory agent

UsesA deuterated topical corticosteroid used as an anti-inflammatory.;Labeled Mometasone, intended for use as an internal standard for the quantification of Mometasone by GC- or LC-mass spectrometry.


Medical uses

Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis) (topical form), allergic rhinitis (such as hay fever) (topical form), asthma (inhalation form) for patients unresponsive to less potent corticosteroids, and penile phimosis. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.

Some low-quality evidence suggests the use of mometasone for symptomatic improvement in children with adenoid hypertrophy.

Mometasone is used to alleviate inflammation and itchiness in skin conditions that respond to treatment with glucocorticoids such as psoriasis and atopic dermatitis.

Nasal mometasone is used in adults (including the elderly) and children over two years of age, to diminish the symptoms such as hay fever (seasonal allergic rhinitis) and other allergies (perennial rhinitis), including nasal congestion, discharge, pruritus, and sneezing and to treat nasal polyps.


USP38 Standard 

Standard adopted

USP38

Items of analysis

Specification

Results

Description

White to off-white powder

Conform

Identification

A:IR  B:HPLC

Conform

Melt Point

About 220℃

220.5℃

Specific Rotation

+56  -+62 °

+58.4°

Loss on drying

≤0.5%

0.31%

Residue On Ignition

≤ 0.1%

0.08%

Heavy Metals

≤30 ppm

Conform

Single impurity

≤1.0%

Conform

Sum impurity

≤2.0%

Conform

Assay

97-102%

99.36%

Particle size

Micronized

Conform


Pharmacology

Mometasone furoate reduces inflammation by causing several effects:

Reversing the activation of inflammatory proteins

Activating the secretion of anti-inflammatory proteins

Stabilizing cell membranes

Decreasing the influx of inflammatory cells

In addition to the glucocorticoid properties of mometasone furoate, it is a very potent agonist of the progesterone receptor as well as a partial agonist of the mineralocorticoid receptor.


IMG_20160508_145340_副本

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