Pharmaceutical Raw Material 17α Estradiol Estrone

Pharmaceutical raw material 17α estradiol Estrone CAS 57-91-0 Weight Loss Female Sex Healthy Hormones 17α-Estradiol Steroids Powder 17α estradiol Estrone Quick Details: CAS No.:53-16-7 Other Names:1,3,5(10)-Estratrien-3-ol-17-one...
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Product Details

Pharmaceutical raw material 17α estradiol Estrone CAS 57-91-0 Weight Loss Female Sex Healthy Hormones 17α-Estradiol Steroids Powder


17α estradiol Estrone 

Quick Details:

CAS No.:53-16-7

Other Names:1,3,5(10)-Estratrien-3-ol-17-one

MF:C18H22O2

EINECS No.:200-164-5

Place of Origin:ShenZhen, China (Mainland)

Type:Pharmaceutical Intermediates

Purity:99%

Brand Name:SENDI

Application:Pharmaceutical Intermediates

Appearance:White Powder

Test method:HPLC

Spec:99%

Water::0.5% Max.

Standard:USP EP JP etc.

Package:Aluminum foil bag

Storage:Cool and dry

Technical support:Available

Total plate count::≤1000cfu/g


Applications:

 

Estradiol is a sex hormone that is present in both males and females, and is the most important form of estrogen in humans. In women, it plays a key role in the development and functioning of the reproductive system, as well as in the growth of certain bones. It also governs the distribution of body fat in women and is the main hormone responsible for the fact that women are shorter than men, on average. Both the ovaries and the adrenal glands produce it.

 

The menstrual cycle in women involves predictable variations in the levels of several hormones, with estradiol being one of them. It is involved in the ovulation process and prepares the inner lining of the uterus for implantation, should the egg be fertilized. Certain tests done on baboons and other primates have indicated that his hormone also plays a continual role in maintaining a pregnancy, helping it to last for the full gestation period.

 

As a sex hormone, it also triggers many of the developments of the reproductive system that begin in puberty. It is present throughout the reproductive years, and declines during and after menopause. This decline is precisely what causes many of the symptoms of menopause, such as hot flashes and night sweats, vaginal dryness, and the loss of bone mass that may lead to osteoporosis.


Specification: 

ItemStandardTest Results

Identification

A.H-NMR:Comply with the structure

Complies

B.LC-MS:Comply with the structure

Complies

C.The IR spectrum of sample should be identical with that of reference standard;

Complies

D.HPLC-ESI-MS

The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.

Complies

Crystallinity

meets the requirements.

Complies

Loss on drying

≤2.0%

0.19%

Heavy metals

≤10 ppm

<10ppm

Water

≤1.0%

0.1%

Sulphated ash

≤0.5%, determined on 1.0 g.

0.009%

Related substances

Unspecified impurities: for each impurity

≤0.10%

<0.10%

Total Impurity

≤0.5%

0.18%

Purity

≥99.0%

99.9%

Assay

99.0%~101.0% (anhydrous substance).

99.9%

Microbiological Analysis

Total plate count

≤1000cfu/g

Complies

Yeast and Moulds

≤100cfu/g

Complies

E. Coli.

Absent

Negative

Salmonella

Absent

Negative

S.aureus

Absent

Negative

Storage

Preserve in well-closed, light-resistant and airtight containers.

Complies


Product description:

17α-Estradiol (17α-E2), or 17-epiestradiol, also known as estra-1,3,5(10)-triene-3,17β-diol, is a minor and weak endogenous steroidal estrogen that is related to 17β-estradiol (better known simply as estradiol).[2] It is the C17 epimer of estradiol.[2] It has approximately 100-fold lower estrogenic potency than 17β-estradiol.[3] The compound shows preferential affinity for the ERα over the ERβ.[2][4] Although 17α-estradiol is far weaker than 17β-estradiol as an agonist of the nuclear estrogen receptors, it has been found to bind to and activate the brain-expressed ER-X with a greater potency than that of 17β-estradiol, suggesting that it may be the predominant endogenous ligand for the receptor.

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