Effective Nootropic SARM Coluracetam MKC-231

99.8% Coluracetam MKC-231 Powder 135463-81-9 Nootropic Better Memory and Brain 1, Coluracetam/ MKC-231 Profile: Product Name: Coluracetam Other Names: MKC-231, BCI-540 Chemical Name: N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide CAS#: 135463-81-9...
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Product Details

99.8% Coluracetam MKC-231 Powder 135463-81-9 Nootropic Better Memory and Brain


1, Coluracetam/ MKC-231 Profile:


Product Name: Coluracetam
Other Names: MKC-231, BCI-540

Chemical Name: N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
CAS#: 135463-81-9
MF: C19H23N3O3
MW: 341.4

Appearance: White crystalline powder, odorless
Assay (on dried basis): 99.8%

Solubility: Easily soluble in water, unsoluble in ethanol

Shelf life: 2 years (powder)
Usage: Brain health drug; Nootropic


2, Applications of Coluracetam/ MKC-231: 

Coluracetam is a nootropic drug of the racetam family. Coluracetam was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depression disorder (MDD), after being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California. Findings from its Phase 2a clinical trials have suggested that it would be an ideal medication for co-morbid MDD with generalized anxiety disorder (GAD). BrainCells Inc is currently out-licensing the drug for this purpose. It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.


Coluracetam enhances high-affinity choline uptake (HACU) which is the rate-limiting step of acetylcholine (ACh) synthesis, and is the only known choline uptake enhancer to currently exist. Studies have shown Coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins. Subsequent studies have shown that it may induce long-lasting procognitive effects by changing the choline transporter regulation system.


Coluracetam Functions
Enhance mental intelligence
Boost memory and leaning capabilities
Improve brain power to solve problems and protect it from any chemical or physical injury
Enhance motivation level
Enhance the control of cortical/subcortical brain mechanism
Improve sensory perception


Coluracetam Dosing

Colouracetam is easily available and sold through online vendors as a dietary supplement in the United States. Dose for dose Colouracetam's potency is nearly twice that of noopept, making it require lower amounts while offering many similar effects. Due to its short acting and acute nature, the preferred ROAs are generally insufflation, sublingual, or vaporisation, though it is still active orally.

The active dose range of this compound is between 5 and 20mg. This is much smaller than comparable doses of the racetam class of drugs (piracetam, oxiracetam, phenylpiracetam, etc.). Dosages higher than 20mg do not seem to offer any additional benefit.

 
3, COA of Coluracetam/ MKC-231 Powder:


Analysis TestSpecificationResult
DescriptionWhite crystalline powder, odorlessConform
SolubilityEasily soluble in water, unsoluble in ethanolConform
PH6.0~7.56.9
Solution clarity and colorSolution should be clear and colorlessConform
Related substances5'CMP 0.3%
Simple impurity
Total other impurity
0.01%
0.03%
0.10%
Chloride0.05%Conform
Ammonium0.05%Conform
Fe0.01%Conform
Phosphate0.1%Conform
Loss on drying≤6.0%1.3%
Heavy metals0.002%Conform
Arsenide0.0001%Conform
Bacterial Endotoxins0.3EU/mgConform
Microbial LimitConformConform
Assay (on dried basis)≥99.0%99.8%

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