GW-0742 SARMS Muscle Care Supplement GW0742 GW 0742

GW-0742 CAS 317318-84-6 SARMS Muscle Care Supplement GW0742 GW 0742 Welcome to Contact Mitchell For more details Directly: sarms gw0742 capsules Purity:99% MF:C21H17F4NO3S2 MW:471.5 Test method:HPLC Appearance:White Powder GW-0742...
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Product Details

GW-0742 CAS 317318-84-6 SARMS Muscle Care Supplement GW0742 GW 0742


Product Name:sarms gw0742 capsules

Purity:99%

MF:C21H17F4NO3S2

MW:471.5

Test method:HPLC

Appearance:White Powder

Item:

GW0742

Specifications:

99%

Appearence:

White Powder

Packaging:

Foli Bag/ Paper Drum/Carton

MOQ:

10g

Delivery Time:

1-3 Working Days

Payment:

Money grams  West Union  Bitcoin Banktransfer

Shelf Time:

2 year 

Storage:

Keep Dry and Keep away from Sunlight

Main Export Country

The Amercias, Europe, Southeast Asia


GW-0742 Introduction:

GW 0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes. GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay.


GW-0742 shows activity against hPPARα, hPPARγ and hPPARδ with EC50 of 1.1 μM, 2 μM and 1 nM, respectively, in cell based transactivation assay. GW-0742 (0.2 μM and 1 μM) significant increases in reporter activity of PPARβ/δ in N/TERT-1 keratinocytes. GW0742 (1 μM) results in significant inhibition in the average number of N/TERT-1 keratinocytes.


GW-0742 at 100 μM produces a pronounced increase in c-Jun expression at 6 hours in cerebellar granule neuron cultures. GW0742 at 100 μM increases PPARα-mediated transactivation dependent on the presence of 1.5% BSA in MCF-7 cells.


GW-0742 Function:

GW 0742 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue , and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome , most likely by stimulating fatty acid oxidation .

GW0742 has been proposed as a potential treatment for obesity and related conditions , especially when used in conjunction with a synergistic compound AICAR , as the combination has been shown to significantly increase exercise endurance in human.


How GW0742 Works?

The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR). Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations. A unique spectroscopic property of GW0742 was identified as well. In the presence of rhodamine-derived molecules, GW0742+ increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner.

The GW0742-inhibited NR-coactivator binding resulted in a reduced expression of five different NR target genes in LNCaP cells in the presence of agonist. Especially VDR target genes CYP24A1, IGFBP-3 and TRPV6 were negatively regulated by GW0742. GW0742 is the first VDR ligand inhibitor lacking the secosteroid structure of VDR ligand antagonists. Nevertheless, the VDR-meditated downstream process of cell differentiation was antagonized by GW0742 in HL-60 cells that were pretreated with the endogenous VDR agonist 1,25-dihydroxyvitamin D3.


GW 0742 Usages:

GW 0742 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue , and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome , most likely by stimulating fatty acid oxidation .


GW0742 has been proposed as a potential treatment for obesity and related conditions , especially when used in conjunction with a synergistic compound AICAR , as the combination has been shown to significantly increase exercise endurance in human.


Overseas Warehouse

 Australia

Warehouse 6 45-53 davies road, padstow nsw 2211

United States

Warehous 1937 Davis Street, Ste. E ,San Leandro, CA 94577

 FAQ:

1, Can I buy a sample for evaluation? 

Yes, a small percentage of items are available for single-unit sample purchases online. To make it easier for our customers to locate these items, a separate section in our store will be created soon. For now, if an item offers samples, Click on the link to order the sample.


2, How to make payment? 

We accept payment by telegraphic transfer (T/T) and Western Union Money grams ,  Bitcoin AND Banktransfer.


3,How much does shipping cost? 

Shipping costs vary according to the shipping method and your ship-to country. For your easy reference, the estimated shipping cost you see in your shopping cart is based on courier shipping to the United States. The system will indicate the actual shipping cost based on your selected shipping method and ship-to country when you checkout and before you commit to the purchase. Generally, shipping to the UK and other Western European countries is slightly more expensive than to the USA. And shipping to Asia is slightly less expensive than to the USA.


4,Does the shipping cost cover local taxes, import duties, and other import-related costs? 

The shipping cost does not cover any local taxes, import duties, customs clearance, or any other import-related costs levied by your government. The buyer is responsible for these import-related costs. Please check with your local customs office for more information.



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