DSIP Delta Sleep Well Inducing Peptide 2mg

DSIP Delta Sleep Inducing Peptide 2mg for Well Sleep

Dsip 2mg/Vail 10Vails/box Polypeptide Delta Sleep Inducing Peptide for bodybuilders sleep well CAS 62568-57-4

Basic Info: 

Lyophilized Powder Peptides Dsip (Delta Sleep Inducing Peptide)

Unit Size : 2 mg/vial

Purity: 99.9% min

Other name : Delta sleep-inducing peptide (DSIP) ; DSIP CAS#: 62568-57-4

DSIP Formula: C35H48N10O15 ; DSIP Molecular Weight: 848.81

Place of Origin: China

Standard: USP  Certification: SGS ; Method of Analysis: HPLC

Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18 C. Upon reconstitution of the peptide it should be stored at 4 C between 2-21 days and for future use below -18C.

DSIP Function:

Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies

Roles in endocrine regulation

Decreases basal corticotropin level and blocks its release.

Stimulates release of luteinizing horm (LH).

Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion. 

Delta Sleep Inducing Peptide DSIP Description: 

Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.

Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.

Sleep Inducing Peptide DSIP effects :

DSIP significantly increased heart rate, decreased HRV and, paradoxically, significantly reduced delta rhythm along with reducing burst suppression and increasing BIS at 25 nmol kg(-1) during isoflurane anaesthesia. DSIP also significantly altered bilateral symmetry of EEG.

DSIP probably reduced parasympathetic tone and decreased (lightened) the depth of anaesthesia measured using BIS.

DSIP(Delta sleep-inducing peptide) METHODS:
Twenty-four female ASA I or II patients gave written, informed consent to a protocol approved by our local research ethics committee. Twelve were randomly assigned as controls to receive saline. The other 12 were randomly allocated to receive one of three intravenous bolus doses of DSIP (Clinalfa) at 25, 50 or 100 nmol kg(-1). The first administration of DSIP was while awake and the second after induction of anaesthesia with propofol and maintenance with isoflurane. BIS and EEG parameters were measured continuously using a bilateral electrode montage.

DSIP Abstract:

Since the turn of the century, it has been postulated that humoral factors induce sleep. Many compounds were proposed as sleep-factors, but only two of the sleep-peptides have been purified to homogeneity and characterized, so far. One of them, DSIP, was shown to be a nonapeptide of MW 849 and to induce mainly delta-sleep in rabbits, rats, mice, and humans, whereas in cats, the effect on REM sleep was more pronounced. A U-shaped activity curve was determined for the dose as well as for the time of infusion. DSIP-like material was found by RIA and immunohistochemistry in brain and by RIA in peripheral organs of the rat as well as in plasma of several mammals. In addition to sleep, the peptide also has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal.

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