Peptides Gonadorelin Pituitary Release Hormone

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Product Details

 Injectable Lyophilized Peptide Gonadorelin CAS 34973-08-5 (2mg/Vial and 10mg/Vial) for Muscle Building



Quick Details: 

Product name: Gonadorelin

CAS No.:34973-08-5

Other Names: Gonadorelin Acetate

MF:C55H75N17O13

EINECS No.:n/a

Place of Origin: ShenZhen, China (Mainland)

Type: Antibiotic and Antimicrobial Agents, Endocrine System Agents, Urinary System Agents

Grade Standard:Medicine Grade

Usage: Gonadorelin is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. 

Brand Name: SENDI

Purity:NLT 99.9%

Product Type: API Active pharmaceutical ingredient

Appearance: White or slightly yellowish powder

Related substances (HPLC):Total impurities: NMT 2.0% Any impurity: NMT 1.0%

Water (Karl Fischer):NMT 7.0 %

Acetic acid (HPLC):4.0% to 7.5%

Peptide Content:NLT 80.0%

pH Value:5.0~7.0 0.2mg/ml aqueous(CO2 free water)solution

Specific optical rotation:-54° to -66°


Gonadorelin is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. 

Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease. 

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Descriptions:

Gonadorelin is a medicine that is the same as gonadotropin-releasing hormone (GnRH) that is naturally released from the hypothalamus gland. GnRH causes the pituitary gland to release other hormones (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]). LH and FSH control development in children and fertility in adults.
Gonadorelin is used to test how well the hypothalamus and the pituitary glands are working. It is also used to cause ovulation (release of an egg from the ovary) in women who do not have regular ovulation and menstrual periods because the hypothalamus gland does not release enough GnRH.
Gonadorelin is a hormone that is produced naturally by the hypothalamus in the brain. It is also known as gonadotrophin-releasing hormone or GnRH.
Gonadorelin stimulates the pituitary gland in the brain to release the sex hormones luteinising hormone (LH) and follicle stimulating hormone (FSH). In women, FSH stimulates the production of oestrogen and the development of eggs in the ovaries. LH stimulates the ovaries to release an egg (ovulation). In men, LH stimulates the testicles to produce the hormone testosterone and FSH stimulates the testicles to produce sperm.
Gonadorelin is given by injection to check whether the pituitary gland is producing LH and FSH in the correct levels. This can help in the diagnosis of various hormonal disorders, including infertility, delayed puberty and hypogonadism.


Gonadorelin Acetate

Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. 
GnRH is available as gonadorelin hydrochloride )and gonadorelin diacetate tetrahydrate use. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease. 

Application of Gonadorelin Acetate
Gonadorelin is used to test how well the hypothalamus and the pituitary glands are working. It is also used to cause ovulation (release of an egg from the ovary) in women who do not have regular ovulation and menstrual periods because the hypothalamus gland does not release enough GnRH.


Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.

The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.


Specification

Product Name

Gonadorelin Acetate

Shelf Life

2 years

Appearance

White or slightly yellowish powder

Purity (HPLC) :

NLT 98.0%

Related substances (HPLC)

Total impurities: NMT 2.0%
Any impurity: NMT 1.0%

Water (Karl Fischer)

NMT 7.0 %

Acetic acid (HPLC)

4.0% to 7.5%

Specific optical rotation
(c = 1.0, 1% acetic acid)

-54° to -66°

Solubility 

Soluble in water at a concentration of 10 mg/mL to give a clear solution not more intensely colored than reference solution Y5

Assay(anhydrous and acetic acid-free substance)

95.0% to 102.0%

Storage

Preserve in tight containers. Store at controlled room temperature 2 to 8°C

Extra Details:

GnRH, also known as gonadoliberin, follicle-stimulating hormone-releasing hormone (FSH-RH), luteinizing hormone-releasing hormone (LHRH) and by various other names in its endogenous form and as gonadorelin (INN) in its pharmaceutical form, is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and released from GnRH neurons within the hypothalamus. 

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