Polypeptide Hormones Desmopressin Acetate

99% Purity Desmopressin Acetate as Urinary System Medication CAS 16679-58-6 A ctive Pharmaceutical Ingredient Desmopressin Acetate Desmopressin Acetate 16679-58-6 Lowest Price Hot Sales What is desmopressin tabs, and how does it work...
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 99% Purity Desmopressin Acetate as Urinary System Medication CAS 16679-58-6Active Pharmaceutical Ingredient

Desmopressin Acetate 

Desmopressin Acetate 16679-58-6 Lowest Price Hot Sales

CAS No.:16679-58-6Other Names:Desmopressin Acetate MF:C46H64N14O12S2
MW.:1069.217Place of Origin:ShenZhen, China (Mainland)Type:Vitamins, Amino Acids and Coenzymes
Grade Standard:Medicine Grade

Purity:>99%, >99%Grade:Food and pharmaceutical gradeFunction:nutritional supplement
quality:High qualityserve:7*24Shelf life:2 Years

What is desmopressin tabs, and how does it work (mechanism of action)?
Desmopressin is a man-made analogue of vasopressin which is the body's natural anti-diuretic hormone released by the pituitary. It works by increasing water permeability in renal tubular cells, which decreases urine volume and increases urine concentration. In people with diabetes insipidus due to trauma or surgery in the pituitary region of the brain, it reduces frequent urination and thirst. The FDA approved desmopressin in February 1978.

What brand names are available for desmopressin tabs?
DDAVP, Stimate
Is desmopressin tabs available as a generic drug?
Do I need a prescription for desmopressin tabs?
What are the side effects of desmopressin tabs?
Side effects of Desmopressin are:

abdominal pain, and
(pink eye).
Changes in blood pressure, low sodium levels, and increased heart rate may occur.

Dosage Forms :

Desmopressin is one of the few medicines that offers a nasal spray in addition to the tablet and the orodispersible tablet. Due to the low molecular weight, the hormone enters the bloodstream well enough through the nasal mucosa. However, the indication for nocturnal enuresis nocturna has been withdrawn because the tablet form has been shown to be safer to use. The orodispersible tablet, which has been approved in Germany since 1 June 2011 and has been marketed in other countries for some time, is intended to ensure safer absorption and effectiveness. Due to the better bioavailability, a lower active ingredient load is possible with the same effect. Minirin is also available as an infusion solution for intravenous and subcutaneous administration.

What is the dosage for desmopressin tabs?
Central diabetes insipidus:
Adults and children 12 years of age and older: Initiate with 0.05 mg by mouth every 12 hours, may titrate up to 0.1 to 1.2 mg divided every 8 to 12 hours.
Children of 4 years to under 12 years of age: Initiate with 0.05 mg by mouth every 12 hours, may titrate up to 0.1 to 0.8 mg divided every 8 to 12 hours.
The intranasal dose for adults and children older than 12 years old is 10 to 40 mcg per day or divided and given in 2 or 3 doses (every 8 or 12 hours). The dose for children 3 months to 12 years is 5 to 30 mcg daily or divided and given every 12 hours.
The intravenous dose for adults and children older than 12 years of age is 2 to 4 mcg daily. Children 3 months to 12 years old should receive 0.1-1 mcg per day or divided and given every 12 hours.
Primary nocturnal enuresis:

Adults and children 6 years of age and older: 0.1 to 0.2 mg orally at bedtime. (May increase up to 0.6 mg if necessary)

Desmopressin is a synthetic analog of the body's own arginine vasopressin (AVP or ADH = antidiuretic hormone) and an agonist at the AVP receptors. It differs from this physiological hormone from the posterior pituitary but in the receptor affinity: While AVP with similar affinity at the V1 receptor, which is mainly responsible for vasoconstriction, as binds to the V2 receptor, desmopressin is unequally affine the V2 receptor and negligible the V1 receptor. 

The V2 receptor in turn is mainly responsible for the water retention in the collecting tubes of the kidney. When activated, it causes the incorporation of aquaporins into cell membranes that allow water molecules to pass through. As a result, the urine is dehydrated / thickened and retained more water in the body.

There are also other effects of the V2 receptor: It triggers the release of Von Willebrand factor and the expression of P-selectin during the exocytosis of Weibel-Palade bodies of endothelial cells. 


Desmopressin is an antidiuretic. It inhibits the massive water excretion typically occurring in central diabetes insipidus. This significantly improves the quality of life of affected patients.

It is also approved for the treatment of traumatic polyuria and polydipsia, as well as other diseases associated with ADH deficiency, such as pituitary surgery or craniocerebral trauma. It is also used as a diagnostic tool for the differential diagnosis of diabetes insipidus. 

Another area of application is the treatment of nocturnal bedwetting (enuresis nocturna).

Desmopressin may also be given as an antihemorrhagic agent e.g. In haemophilia, uraemic thrombocytopathy or Willebrand-Jürgens syndrome.

Side effects 

The more common side effects are generally related to pharmacodynamics. Especially with increased fluid intake there is an increased water retention (Desmopressin is a highly potent antidiuretic), thereby increasing the volume with relatively lack of electrolyte. Warning signs are headache, nausea / vomiting and weight gain. In rare severe cases, it can lead to cerebral edema, sometimes associated with seizures or consciousness restrictions.

Furthermore, there are still rare side effects such as allergies and cardiovascular problems (eg angina pectoris), which are associated with the increase in blood pressure.



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