Taltirelin Acetate Treatment Spinocerebellar Degeneration

CAS 103300-74-9 Taltirelin Acetate Used in the treatment of spinocerebellar degeneration Taltirelin is a synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30-100-fold more potent...
Chat Now

Product Details

CAS 103300-74-9 Taltirelin Acetate Used in the treatment of spinocerebellar degeneration


Taltirelin is a synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30-100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Both antinociceptive and neuroprotective.

Product Name: Taltirelin Acetate

CAS: 103300-74-9

MF: C17H23N7O5

MW: 405.41

Product Categories: Peptide;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals

Uses: Analog of thyrotropin releasing hormone TRH, with pronounced CNS activity. 


Position for injection

1) For blepharospasm:the injection should be taken intramuscularly at several points of upper and lower lids, i.e.,taking 4 to 5 points of injection into medial and lateral part of orbicularis oculi or temporal lateral canthus.

2) For hemifacial spasm:besides the points mentioned above,three other points on middle,lower face and cheek should be given intramuscularly.Botulinum may be given at the points of two sides of eyebrow,upper lip or the lower jaw according to the diseases.

3) For strabismus:the Botulinum is injected using a coaxial electrode needle with electromyographic guidance or amplifier under topical anesthesia of 0.5% Decarine.The injections into extraocular muscles are selected according to the type and position of strabismus.


Dosage

1) For blepharospasm and hemifacial spasm:the injection could be given following above instructions.The initial dose of each point is 2.5 U/ 0.05ml or 2.5 U / 0.1 ml. If the initial treatment is considered insufficient one week later,a supplementary injection may be given.

Double dose of 5 U / 0.1 ml could be given to recrudescent patients. But the limitation of total dose of 55 U for one injection and 200 U for one month should not be exceeded.

2) For strabismus:for vertical and horizontal muscle strabismus of less than 20 prism diopters,the initial dose into each muscle is 1.25-2.5 U;for horizontal strabismus of 20-40 prism diopters,the initial dose into each muscle is 2.5 U;for horizontal strabismus of 40-50 prism diopters,the initial dose into each muscle is 2.5 U and can be increased (to 5.0 each time) depending on the response;for persistent VI cranial nerve paralysis lasted for more than one month,1.25-2.5 U dose could be injected into medial rectus.

The injecting volume into each muscle should not exceed 0.1 ml.


STORAGE:

Store at a temperature of -5 to -20ºC. Do not use after the expiry date.


Self-introduction

This is Mitchell from ShenZhen SENDI Biotechnology Co.,Ltd. We are the professional supplier of peptide products in China over 10 years. we have Professional Lab to confirm the Quality and Serive for all clients in long-term run cooperation.

Our Company as a Pharmaceutical Raw Material Manufacturer specialize in R&D the New Drugs and Producing the Generic Medicine:

Amino Acids&Vitamins

Pharmaceutical Polypeptide,

Comestic Polypeptide,

Veterinary Peptide and 

Pharmaceutical APIs.

Due to of the high quality and good service, They have been exported more than 30 countries. 

Sincerely hope to have a chance to cooperate with you.


COA:

Item

Standard

Identification

A.H-NMR:Comply with the structure

B.LC-MS:Comply with the structure

C.The IR spectrum of sample should be identical with that of reference standard;

D.HPLC-ESI-MS

The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.

Crystallinity

meets the requirements.

Loss on drying

≤2.0%

Heavy metals

≤10 ppm

Water

≤1.0%

Sulphated ash

≤0.5%, determined on 1.0 g.

Related substances

Unspecified impurities: for each impurity

≤0.10%

Total Impurity

≤0.5%

Purity

≥99.0%

Assay

99.0%~101.0% (anhydrous substance).

Microbiological Analysis

Total plate count

≤1000cfu/g

Yeast and Moulds

≤100cfu/g

E. Coli.

Absent

Salmonella

Absent

S.aureus

Absent

Storage

Preserve in well-closed, light-resistant and airtight containers.

CAS 103300-74-9 .jpg


What's more you get all this at your doorsteps. For more information on who we are and what we do please drop us a mail and we would love to get back to you.


Hot Tags: taltirelin acetate treatment spinocerebellar degeneration, China, suppliers, discount, buy, bulk, pricelist, high quality, in stock

Inquiry

You Might Also Like